Factors associated with anakinra effectiveness and risk of infection in crystal-related flares
Authors' conclusion
This large real-life study supports the effectiveness and overall safety of anakinra in the management of acute CRD flares.
Study context
- Population
- Adults treated with anakinra for a crystal-related disease (CRD) flare, single centre, January 2011 to July 2024; CRD confirmed by crystals in synovial fluid or characteristic radiological features
- Participants
- 292 adults
- Outcome
- Treatment effectiveness based on the treating physician's global clinical judgment; failure = insufficient clinical response requiring treatment escalation or persistent symptoms
Methodological detailssingle-centre, observational, multivariable analysis
- Single-centre
- Observational
- Multivariable analysis
Main finding
As reported in the abstract
Effectiveness of anakinra · median treatment duration of 3 days
Anakinra
92.8%
Observational data: associations, not effects.
Further findings
Factors independently associated with treatment failure (multivariate analysis)
- Longer CRD duration, OR
- 1.11 (95% CI 1.03-1.19)
- History of diabetes, OR
- 4.00 (95% CI 1.25-14.29)
Factors associated with infection risk
- No variable was independently associated with infection risk
Safety
| Outcome | Values |
|---|---|
| Infection within 1 month after anakinra initiation | Anakinra 4.5% |
- Infection within 1 month after anakinra initiation — Median delay to infection, days
- 11
Original publication
Factors associated with anakinra effectiveness and risk of infection in crystal-related flares. Rheumatology (Oxford). Published 2 April 2026. doi:10.
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