Spondyloarthritis & psoriatic arthritis
Factors Associated With Treatment Pathways in Early Axial Spondyloarthritis: A Multistate Analysis of the 10-Year Follow-Up of the DESIR Cohort
Authors' conclusion
Different time profiles for the management of patients with axSpA were identified, including in those abstaining from treatment up to a significant proportion of patients treated with csDMARDs.
Study context
- Population
- Patients with axial spondyloarthritis (axSpA) from the French prospective cohort DESIR686/708 (96.9%) analysed
- Participants
- 686 patients
- Outcome
- Treatment states (no treatment, NSAIDs, csDMARDs, TNFi) and factors associated with transitions (treatment intensification) over time
- Follow-up
- 10-year follow-up
Methodological detailsmultistate model, multivariable Cox models, 10-year follow-up
- Multistate model
- Multivariable Cox models
- 10-year follow-up
Main finding
As reported in the abstract
- Untreated at cohort entry
- 199 (29%)
- NSAIDs at cohort entry
- 427 (62.2%)
- csDMARDs at cohort entry
- 60 (8.7%)
- TNFi at cohort entry
- 0
- Proportion of follow-up time on NSAIDs
- 46.4%
- Proportion of follow-up time on TNFi
- 24.4%
Observational data: associations, not effects.
Original publication
Factors Associated With Treatment Pathways in Early Axial Spondyloarthritis: A Multistate Analysis of the 10-Year Follow-Up of the DESIR Cohort. J Rheumatol. Published 15 February 2024. doi:10.
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