Factors associated with severity and mortality of COVID-19 in patients with connective tissue diseases and rheumatoid arthritis: A nation-wide, population-based analysis of the French national medico-administrative SNDS database
Authors' conclusion
In CTD patients with COVID-19, use of glucocorticoids, rituximab, and certain immunosuppressants was associated with severity and mortality, while TNF inhibitors and methotrexate were protective.
Study context
- Population
- Adult patients with Connective Tissue Diseases (CTDs) (RA, systemic lupus, Sjögren's disease, inflammatory myopathies, SSc), French nationwide claims and hospitalization database, 202075.5% female
- Participants
- 329,276 patients
- Outcome
- Hospitalization, severe inpatient stays (ICU admission or in-hospital mortality) and in-hospital mortality with COVID-19
- Follow-up
- January 1st to December 31st, 2020
Methodological detailsnation-wide, population-based, claims and hospitalization database (SNDS)
- Nation-wide
- Population-based
- Claims and hospitalization database (SNDS)
Main finding
As reported in the abstract
COVID-19 hospitalization, ICU admission and death · 2020
- Hospitalized with COVID-19
- 3,389 (1.03%)
- Required ICU admission
- 973 (0.29%)
- Died
- 713 (0.22%)
- Hospitalized, severe stay or died: predominantly male, older, with comorbidities
- P<0.0001 for all
- Higher risk of hospitalization, severe inpatient stay and death with GC, LEF, SSZ, mycophenolate derivatives and RTX
- P<0.05 for all
- TNFi associated with reduced hospitalizations and severe inpatient stays
- P<0.05 for all
- MTX use associated with decreased mortality
- P<0.01
Observational data: associations, not effects.
Original publication
Factors associated with severity and mortality of COVID-19 in patients with connective tissue diseases and rheumatoid arthritis: A nation-wide, population-based analysis of the French national medico-administrative SNDS database. Joint Bone Spine. Published 17 November 2024. doi:10.
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