Extracorporeal membrane oxygenation for acute lung injury in idiopathic inflammatory myopathies—a potential lifesaving intervention
Authors' conclusion
In the patients exposed to ECMO in this case series, 14 were successfully bridged to recovery or transplant, while 8 died in the ICU.
Study context
- Population
- Idiopathic inflammatory myopathies (IIM) patients who underwent extracorporeal membrane oxygenation (ECMO) for acute IIM-related lung injury, tertiary care centres in Belgium, Canada, Denmark, USA and Sweden50% female
- Participants
- 22 patients
- Exposure
- Bridged to recovery vs Bridged to transplant vs Died in the intensive care units (ICU)
- Bridged to recoveryn = 6
- Bridged to transplantn = 8
- Died in the ICUn = 8
- Outcome
- Outcome after ECMO
Methodological detailsmulticentre, retrospective review
- Multicentre
- Retrospective review
Main finding
As reported in the abstract
Observational data: associations, not effects.
Further findings
| Outcome | P value |
|---|---|
| Age, died in ICU vs bridged to recoveryThose who died were older | P = 0.03 |
| Median Charlson comorbidity index, died in ICU vs bridged to recoveryHigher in those who died | P = 0.05 |
Safety
| Outcome | Bridged to recovery | Died in the ICU | P value |
|---|---|---|---|
| ECMO-related complicationsBridged to recovery vs Died in the ICU · similar frequencies | 33% | 50% | P = 0.94 |
Original publication
Extracorporeal membrane oxygenation for acute lung injury in idiopathic inflammatory myopathies—a potential lifesaving intervention. Rheumatology (Oxford). Published 25 May 2024. doi:10.
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