Expression quantitative trait loci analysis in rheumatoid arthritis identifies tissue specific variants associated with severity and outcome
Authors' conclusion
This analysis highlights the need to explore functional consequences of genetic associations in disease tissue.
Study context
- Population
- Treatment-naïve patients with rheumatoid arthritis (RA) from the Pathobiology of Early Arthritis Cohort
- Participants
- 85 vs 51
- Comparison
- Synovium vs blood expression quantitative trait locus (eQTL)
- Synoviumn = 85
- Bloodn = 51
- Outcome
- eQTL genes
Methodological detailseQTL analysis, RNA-Sequencing of synovial biopsies and blood
- eQTL analysis
- RNA-Sequencing of synovial biopsies and blood
Main finding
As reported in the abstract
Synovium
898
eQTL genes
- eQTL genes in common to both synovium and blood
- 232
Original publication
Expression quantitative trait loci analysis in rheumatoid arthritis identifies tissue specific variants associated with severity and outcome. Ann Rheum Dis. Published 15 February 2024. doi:10.
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