Exploring factors contributing to frailty in Chinese patients with rheumatoid arthritis: Validation of a tailored assessment tool
Authors' conclusion
The Chinese version of the CRAF is a reliable and valid tool for assessing frailty in RA participants.
Study context
- Population
- Chinese participants with rheumatoid arthritis (RA)
- Participants
- 1,288 participants
- Exposure
- Chinese Comprehensive Rheumatologic Assessment of Frailty (CRAF) vs FRAIL Scale
- Outcome
- Psychometric properties of the Chinese CRAF and factors associated with frailty
Methodological detailstranslation and cultural adaptation (modified Brislin method), psychometric validation, multivariate ordered logistic regression
- Translation and cultural adaptation (modified Brislin method)
- Psychometric validation
- Multivariate ordered logistic regression
Main finding
As reported in the abstract
Psychometric properties of the Chinese CRAF
| Group | Cronbach's alpha | Intraclass correlation coefficient | Item-CVI range | Average CVI |
|---|---|---|---|---|
| CRAF | 0.75 | 0.92 | 0.80 to 1.00 | 0.92 |
CRAF
Cronbach's alpha0.75
Intraclass correlation coefficient0.92
Item-CVI range0.80 to 1.00
Average CVI0.92
- CRAF vs FRAIL Scale: P < 0.001 — significant positive correlation
- CRAF vs FRAIL Scale: P = 0.041 — CRAF better discriminatory power
Observational data: associations, not effects.
Further findings
Factors significantly associated with frailty
- Disease duration, pain intensity, physical function limitations, use of MTX, NSAIDs, GCs and bDMARDs, hypertension, diabetes, CVD, stroke/transient ischemic attack, pulmonary disease, diminished grip strength, smoking, depression, lack of social participation
Original publication
Exploring factors contributing to frailty in Chinese patients with rheumatoid arthritis: Validation of a tailored assessment tool. Semin Arthritis Rheum. Published 13 December 2025. doi:10.
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