Frailty as an indicator of adverse health outcomes in rheumatoid arthritis: a multicenter cross-sectional study
Authors' conclusion
Frailty is a significant indicator of adverse health outcomes in RA, and even pre-frailty signals a higher vulnerability to poor health outcomes.
Study context
- Population
- Participants with Rheumatoid Arthritis (RA), Tianjin, China, November 2023 to August 2024
- Participants
- 823 participants
- Exposure
- Frailty and pre-frailty vs robust status
- Outcome
- Disease activity, physical function, anxiety, depression and HRQoL
Methodological detailsmulticenter, multiple linear regression, full adjustment for demographic, lifestyle and clinical covariates
- Multicenter
- Multiple linear regression
- Full adjustment for demographic, lifestyle and clinical covariates
Main finding
As reported in the abstract
Association of frailty status with health outcomes (fully adjusted)
- Frailty: significantly associated with higher disease activity, poorer physical function, elevated anxiety and depression, and lower health-related quality of life (HRQoL)
- all P < 0.001
- Pre-frailty: significantly associated with higher disease activity, worse physical function, greater depression, and lower HRQoL
- all P < 0.001
- Pre-frailty: not associated with anxiety
- P = 0.786
Observational data: associations, not effects.
Original publication
Frailty as an indicator of adverse health outcomes in rheumatoid arthritis: a multicenter cross-sectional study. Arthritis Res Ther. Published 26 January 2026. doi:10.
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