Vasculitis & polymyalgia rheumatica
Evidence on treat to target strategies in polymyalgia rheumatica and giant cell arteritis: a systematic literature review
Authors' conclusion
This SLR provides evidence and highlights the knowledge gaps on T2T strategies in PMR and GCA, informing the task force developing T2T recommendations for these diseases.
Study context
- Population
- Randomised clinical trials (RCTs) and non-randomised interventional studies on to Target (T2T) strategies, treatment targets and outcomes in PMR and GCAmanuscripts included
- Participants
- 76 participants
- Outcome
- Outcomes applied in RCTs in PMR and GCA
Methodological detailssearches of Medline, EMBASE, Cochrane Library, clinicaltrials.gov to May 2022 and EULAR/ACR abstracts 2019-2021, eleven PICO questions, independent selection, data extraction and risk of bias assessment by two investigators, 7809 abstracts screened; 397 selected for detailed review
- Searches of Medline, EMBASE, Cochrane Library, clinicaltrials.gov to May 2022 and EULAR/ACR abstracts 2019-2021
- Eleven PICO questions
- Independent selection, data extraction and risk of bias assessment by two investigators
- 7809 abstracts screened; 397 selected for detailed review
Main finding
As reported in the abstract
PMR RCTs: treatment outcomes (particularly cumulative glucocorticoids (GC) dose and GC tapering)
90.9%
PMR RCTs: clinical, laboratory and safety outcomes (each)
63.3%
GCA RCTs: prevention of relapses
72.2%
GCA RCTs: remission, treatment-related and safety outcomes (each)
67.0%
Further findings
Outcomes applied in PMR RCTs
- Treatment outcomes (esp. cumulative GC dose and GC tapering), % of RCTs
- 90.9%
- Clinical, laboratory and safety outcomes, each
- 63.3%
Outcomes reported in GCA RCTs
- Prevention of relapses
- 72.2%
- Remission, treatment-related and safety outcomes, each
- 67.0%
Original publication
Evidence on treat to target strategies in polymyalgia rheumatica and giant cell arteritis: a systematic literature review. Rheumatology (Oxford). Published 6 September 2023. doi:10.
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