Systemic sclerosis & Raynaud's
Evaluation of left cardiac chamber function with cardiac magnetic resonance and association with outcome in patients with systemic sclerosis
Authors' conclusion
In patients with SSc, LARS was independently associated with the presence of NYHA class II-IV heart failure symptoms. Although both LARS and LV GLS were associated with all-cause mortality, only LARS provided incremental value over all evaluated variables known to be prognostically important in patients with SSc.
Study context
- Population
- Patients with SSc who underwent cardiovascular magnetic resonance (CMR) imaging at two tertiary referral centres (median age 54 [IQR 46–64] years, 42% male)
- Participants
- 100 patients
- Outcome
- Association of LARS and LV GLS with NYHA class II-IV heart failure symptoms and all-cause mortality
Methodological detailstwo tertiary referral centres, feature-tracking CMR
- Two tertiary referral centres
- Feature-tracking CMR
Main finding
As reported in the abstract
- Median left ventricular (LV) global longitudinal strain (GLS)
- −21.8%
- Median left atrial reservoir strain (LARS)
- 36%
- LARS independently associated with New York Heart Association (NYHA) class II-IV HF symptoms (multivariable logistic regression), OR per %
- 0.964 (95% CI 0.929, 0.998, P = 0.049)
- All-cause mortality over median follow-up of 37 (21-62) months
- 24 (24%)
- LARS and all-cause mortality (univariable Cox), HR per 1%
- 0.94 (95% CI 0.91, 0.97, P < 0.0001)
- LV GLS and all-cause mortality (univariable Cox), HR per %
- 1.10 (95% CI 1.03, 1.17, P = 0.005)
Observational data: associations, not effects.
Original publication
Evaluation of left cardiac chamber function with cardiac magnetic resonance and association with outcome in patients with systemic sclerosis. Rheumatology (Oxford). Published 28 April 2022. doi:10.
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