Systemic sclerosis & Raynaud's
The effect of silver fibre gloves on Raynaud’s phenomenon in patients with systemic sclerosis: a double-blind randomized crossover trial
Primary result · Mean RCS over timeResult — go to the resultβ 0.067 95% CI −0.006 to 0.19Authors' conclusion
Wearing gloves in SSc patients clearly decreases the RP burden. Our results do not support the hypothesis that increased heat transport of 8% silver fibre gloves is associated with less disease burden as measured in this study by the RCS compared with normal gloves.
Study context
- Population
- SSc patients with RP76 completed
- Participants
- 85 patients
- Comparison
- 8% silver fibre gloves vs normal gloves, each for 6 weeks
- Primary endpoint
- Raynaud Condition Score (RCS) over time (MCID 1.4), assessed three times per week by online questionnaire
Methodological detailsmulticentre, double-blind, crossover, Outcomes evaluated before unblinding using linear mixed models
- Multicentre
- Double-blind
- Crossover
- Outcomes evaluated before unblinding using linear mixed models
Primary result
Mean RCS over time
β
0.067
95% CI −0.006 to 0.19
By group
Silver fibre gloves
3.9
mean · SD 2.3
Normal gloves
3.9
mean · SD 2.3
As reported in the abstract
Secondary outcomes
| Outcome | β (95% CI) |
|---|---|
| Total SHAQ | 0.036 (0.026–0.046) |
- Total Scleroderma-Health Assessment Questionnaire (SHAQ): slightly higher with silver fibre gloves; clinically irrelevant
Safety
Events
| Outcome | Silver fibre gloves | Normal gloves | OR (95% CI) | |
|---|---|---|---|---|
| New digital ulcers | 1 | 3 | 3.2 (0.32–31.1) | |
| 0.050.21520Odds ratio (log scale) |
Original publication
The effect of silver fibre gloves on Raynaud’s phenomenon in patients with systemic sclerosis: a double-blind randomized crossover trial. Rheumatology (Oxford). Published 20 April 2022. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →