Evaluation of depressive and anxiety symptoms in childhood-onset systemic lupus erythematosus: Frequency, course, and associated risk factors
Authors' conclusion
In this sample, depressive and anxiety symptoms were prevalent and persistent. Depressive symptoms correlated with neighborhood-level material deprivation, and family psychiatric history.
Study context
- Population
- Youth aged 8–18 years with childhood-onset SLE (cSLE)mean disease duration 4.3 years
- Participants
- 51 participants
- Outcome
- Prevalence of clinically significant depressive (CES-DC score >15) or anxiety symptoms (SCARED score ≥25)
- Follow-up
- Baseline and > 6 months later
Methodological detailslongitudinal, multivariable linear regression
- Longitudinal
- Multivariable linear regression
Main finding
As reported in the abstract
Clinically significant depressive symptoms
35%
n = 18
Clinically significant anxiety symptoms
35%
n = 18
Observational data: associations, not effects.
Further findings
Factors associated with baseline depressive symptoms (multivariable regression)
| β (95% CI) | P value | |
|---|---|---|
| Neighbourhood-level material deprivation | 4.2 (1.0–7.3) | P = 0.01 |
| Psychiatric condition in a first-degree relative | 7.3 (2.2–12.4) | P = 0.006 |
Psychiatric interview diagnoses at baseline
- Anxiety disorder
- 14% (n = 7)
- Depressive disorders
- 6% (n = 3)
- Post-traumatic stress disorder
- 4% (n = 2)
Adverse childhood events and first-degree relative with psychiatric condition · baseline
- Adverse childhood events
- 40% (n = 20)
- First-degree relative with psychiatric condition
- 37% (n = 18)
Factors associated with baseline anxiety scores
- No associations found between baseline anxiety scores and patient factors
Persistent and new symptoms at follow-up (CES-DC n = 34; Screen for Childhood Anxiety Related Disorders (SCARED) n = 44) · median 13.5 months (IQR 10.5, 18)
- Persistent depressive symptoms
- 18%, n = 6
- Persistent anxiety symptoms
- 16%, n = 7
- Newly present depressive symptoms
- 24%, n = 8
- Newly present anxiety symptoms
- 16% n = 7
Original publication
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