Vasculitis & polymyalgia rheumatica
Eosinophilic giant cell arteritis: A different subset of disease?
Authors' conclusion
Patients with transmural eosinophilic infiltration represent a subset of GCA with cranial disease and more severe inflammation.
Study context
- Population
- Consecutive GCA patients with transmural inflammation at temporal artery biopsy, Santa Maria Nuova Hospital, over a 28-year period
- Participants
- 254 patients
- Exposure
- GCA with transmural eosinophilic infiltration at temporal artery biopsy (TAB) vs without
- Eosinophilic infiltrationn = 22
- Without eosinophilic infiltrationn = 232reference
- Outcome
- Clinical findings, response to therapy and course
Methodological detailsconsecutive patients, matched (age, sex, follow-up duration) subsample for allergic manifestations
- Consecutive patients
- Matched (age, sex, follow-up duration) subsample for allergic manifestations
Main finding
As reported in the abstract
Clinical findings at diagnosis
- Eosinophilic infiltration vs Without eosinophilic infiltration: P = 0.052
- Eosinophilic infiltration vs Without eosinophilic infiltration: P = 0.005
- Eosinophilic infiltration vs Without eosinophilic infiltration: P = 0.045
- Eosinophilic infiltration vs Without eosinophilic infiltration: P = 0.024
- Eosinophilic infiltration vs Without eosinophilic infiltration: P = 0.016
- Eosinophilic infiltration vs Without eosinophilic infiltration: P = 0.001
Observational data: associations, not effects.
Further findings
| Outcome | P value |
|---|---|
| Histological lesionsEosinophilic infiltration vs Without eosinophilic infiltration | P = 0.066 |
| Histological lesionsEosinophilic infiltration vs Without eosinophilic infiltration | P < 0.001 |
| Histological lesionsEosinophilic infiltration vs Without eosinophilic infiltration | P = 0.010 |
Long-term remission and flares
- Similar in the two groups
Allergic manifestations (matched comparison, 21 vs 42)
- Patients with evidence or development of allergic manifestations and/or systemic necrotizing vasculitis findings
- 0
- Blood eosinophil counts at diagnosis normal
- Matched for age, sex and follow-up duration
Original publication
Eosinophilic giant cell arteritis: A different subset of disease? Semin Arthritis Rheum. Published 5 February 2024. doi:10.
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