Entheseal bone remodeling and patient reported outcomes in osteoarthritis – A quantitative [18F]NaF-PET MRI study
Authors' conclusion
Entheseal bone remodeling quantified by [18F]NaF-PET-MRI is associated with patient-reported clinical knee outcomes.
Study context
- Population
- Patients with patello-femoral osteoarthritis (OA) (PFJOA) and healthy controls135 knees
- Participants
- 68 patients
- Outcome
- Association between entheseal [18F]NaF-uptake (anterior patella and tibial tuberosity) and KOOS subscales
Methodological detailssimultaneous [18F]NaF PET-MRI (3.0 T) of both knees, generalized estimating equations, adjusted for MRI-detected changes, age, sex and BMI
- Simultaneous [18F]NaF PET-MRI (3.0 T) of both knees
- Generalized estimating equations
- Adjusted for MRI-detected changes, age, sex and BMI
Main finding
As reported in the abstract
- KOOS sports (worse outcome; significant)
- beta −2.7; p<0.001
- KOOS quality of life (worse outcome; significant)
- beta 3.0; p<0.001
- KOOS PFJ (worse outcome; significant)
- beta 2.3; p=0.001
- KOOS pain (not significant)
- beta −0.8; p=0.18
- KOOS symptoms (not significant)
- beta −0.6; p=0.30
- KOOS activities of daily living (not significant)
- beta −1.1; p=0.06
Observational data: associations, not effects.
Original publication
Entheseal bone remodeling and patient reported outcomes in osteoarthritis – A quantitative [18F]NaF-PET MRI study. Osteoarthritis Cartilage. Published 18 September 2025. doi:10.
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