Elevated plasma monounsaturated fatty acids and their associations with disease activity, adiposity and sex in patients with rheumatoid arthritis: a cross-sectional study
Main findingResult — go to the resultΒ (oleic acid, RA status) 1.4 95% CI 0.33–2.5Authors' conclusion
Circulating MUFAs are associated with RA status, adiposity and disease activity after adjusting for diet, supporting a role for endogenous lipid metabolism in RA.
Study context
- Population
- Individuals with rheumatoid arthritis (RA) and matched controls, recruited 2017–2022
- Participants
- 52 vs 30
- Exposure
- RA vs matched controls
- RAn = 52
- Controlsn = 30reference
- Outcome
- Plasma MUFAs and SCD-1 index (adjusted for age, sex and diet)
Methodological detailsmatched controls, multivariable regression with false discovery rate correction
- Matched controls
- Multivariable regression with false discovery rate correction
Main finding
As reported in the abstract
Β (oleic acid, RA status)
1.4
95% CI 0.33–2.5
Observational data: associations, not effects.
Further findings
Oleic acid and waist-to-hip ratio
- β (oleic acid, waist-to-hip ratio), 95% CI 6.9 to 21
- 14
- Adjusted for age, sex and diet
Among RA: Monounsaturated fatty acids (MUFAs) and DAS28-CRP, sex
- Higher oleic acid and gondoic acid associated with DAS28-CRP
- Palmitoleic acid higher in women, not associated with DAS28-CRP
Metabolic parameters
- RA had lower insulin sensitivity, higher triglycerides and lower physical activity
Original publication
Elevated plasma monounsaturated fatty acids and their associations with disease activity, adiposity and sex in patients with rheumatoid arthritis: a cross-sectional study. RMD Open. Published 16 June 2026. doi:10.
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