From disability to daily life: functional status, quality of life and work productivity in real-world inflammatory arthritis
Authors' conclusion
In this robust real-world study using standardized PROMs, functional decline was associated with progressively worse HRQoL and productivity, with differences statistically significant and clinically meaningful. Moderate-to-severe disability appeared to mark a critical threshold.
Study context
- Population
- Consecutive inflammatory arthritis (IA) patients attending rheumatology clinics in Calgary, Canada, enrolled in the Rheum4U Precision Health Registry (2018–2026)
- Participants
- 1,177 patients
- Exposure
- Health-related quality of life (HRQoL) and work productivity across HAQ-DI functional disability levels
- Outcome
- HRQoL (EQ-5D-5L utility and VAS) and productivity (WPAI: SHP) across functional disability levels (HAQ-DI)
Methodological detailsregistry-based, consecutive patients, real-world
- Registry-based
- Consecutive patients
- Real-world
Main finding
As reported in the abstract
Difference (EQ-5D-5L utility)
0.223
critical threshold for impairment; Minimum important difference (MID) 0.20
Difference (VAS)
25
MID 9.3
Difference (productivity)
40%
MID 20%
- Worsening functional disability associated with progressively lower HRQoL and productivity
- P < 0.001
Observational data: associations, not effects.
Original publication
From disability to daily life: functional status, quality of life and work productivity in real-world inflammatory arthritis. Rheumatology (Oxford). Published 15 June 2026. doi:10.
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