Elevated neutrophil-to-lymphocyte and monocyte-to-lymphocyte ratios are associated with increased flares and elevated cardiovascular disease risk in gout
Main finding · Correlations of NLR and MLR with calprotectin, gout attacks and CVD riskResult — go to the resultOdds ratio 7.5 95% CI 1.7–33.0Authors' conclusion
NLR and MLR are potential biomarkers to predict gout flare risk. An increase in either may indicate an increased risk of CVD morbidity.
Study context
- Population
- Gout patients
- Participants
- 38 patients
- Exposure
- High vs low neutrophil-to-lymphocyte ratio (NLR) or monocyte-to-lymphocyte ratio (MLR)
- Outcome
- Disease activity (total number of acute gout attacks) and 10 year risk of cardiovascular morbidity, in relation to NLR and MLR
Main finding
As reported in the abstract
Correlations of NLR and MLR with calprotectin, gout attacks and CVD risk
Odds ratio
7.5
95% CI 1.7–33.0
High NLR or MLRvs Low NLR or MLR
OR 7.5 (95% CI 1.7–33.0)
- Calprotectin correlated with NLR
- r = 0.56, p = 0.0004
- MLR correlated with total number of gout attacks
- r = 0.39, p = 0.02
- NLR and MLR, but not absolute monocyte or neutrophil counts, significantly correlated with BMI and significantly increased in patients with high cardiovascular disease (CVD) risk
- P < 0.05
Observational data: associations, not effects.
Original publication
Elevated neutrophil-to-lymphocyte and monocyte-to-lymphocyte ratios are associated with increased flares and elevated cardiovascular disease risk in gout. Scand J Rheumatol. Published 17 January 2025. doi:10.
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