Systemic sclerosis & Raynaud's
Effects of Radiotherapy for Malignancy in Systemic Sclerosis: A Systematic Review
Authors' conclusion
Although most patients with SSc do not exhibit significant worsening of SSc manifestations post radiotherapy, there is a variable risk of acute and late toxicity.
Study context
- Population
- Patients with systemic sclerosis (SSc) who subsequently developed cancer and received radiotherapy
- Participants
- 121 patients
- Outcome
- SSc manifestations post radiotherapy
Pooled result
As reported in the abstract
No worsened SSc skin thickening
74.5%
No worsened pulmonary complications
74%
Safety
Radiotherapy toxicity (CTCAE; grade 1–2 nonsevere, grade 3–5 severe)
- Acute adverse effects, nonsevere
- 57.3%
- Acute adverse effects, severe
- 25.8%
- Late adverse effects, nonsevere
- 32.4%
- Late adverse effects, severe
- 24%
- Average rates in retrospective studies
Original publication
Effects of Radiotherapy for Malignancy in Systemic Sclerosis: A Systematic Review. J Rheumatol. Published 1 June 2024. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →