Effects of COVID-19 vaccination on disease activity in patients with rheumatoid arthritis and psoriatic arthritis on targeted therapy in the COVIDSER study
Authors' conclusion
COVID-19 vaccination was not associated with increased rate of flares in patients with RA and PsA.
Study context
- Population
- Vaccinated patients with rheumatoid arthritis (RA) or psoriatic arthritis (PsA) on targeted therapies, COVIDSER registry
- Participants
- 1,765 patients
- Exposure
- Disease activity 6 months after vs 6 months before COVID-19 vaccination; targeted therapies vs TNFi
- RAn = 1,178
- PsAn = 587
- Outcome
- DAS28-based flare rates and categorised disease activity, post vs prevaccination
- Follow-up
- 6 months
Methodological detailsprevaccination vs post-vaccination comparison, log-linear regression, random coefficient model
- Prevaccination vs post-vaccination comparison
- Log-linear regression
- Random coefficient model
Main finding
As reported in the abstract
- Distribution of categorised disease activity and flare rates not significantly modified by vaccination
- No significant change in flare rate after vs before vaccination in RA or PsA
Observational data: associations, not effects.
Further findings
| Outcome | Worsening of disease activity | P value |
|---|---|---|
| DAS28 worsening by treatment vs TNFi (subgroups)RA: JAKi vs RA: TNFi · ±0.531 | 1.436 | P = 0.007 |
| DAS28 worsening by treatment vs TNFi (subgroups)RA: IL-6 inhibitor vs RA: TNFi · ±0.550 | 1.201 | P = 0.029 |
| DAS28 worsening by treatment vs TNFi (subgroups)PsA: IL-12/23 inhibitor vs PsA: TNFi · ±1.906 | 4.476 | P = 0.019 |
DAS28 variation (continuous), random coefficient model
- No significant variations in disease activity after vaccination in RA or PsA
Original publication
Effects of COVID-19 vaccination on disease activity in patients with rheumatoid arthritis and psoriatic arthritis on targeted therapy in the COVIDSER study. RMD Open. Published 16 March 2023. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →