Effect of using the Simple Erosion Narrowing Score or Sharp/van der Heijde score on the power of rheumatoid arthritis clinical trials to detect differences in radiographic progression
Authors' conclusion
SENS appears to be a reasonable alternative to SHS, with only a limited loss of power to show between-group differences in radiographic progression.
Study context
- Population
- Data from two clinical trials in RA (DRESS and BeSt)2 trials
- Comparison
- Simple Erosion Narrowing Score (SENS) vs SHS for power to show between-group differences in radiographic progression
- Primary endpoint
- Power to show a between-group difference in radiographic progression (number of bootstrap replications with a significant difference)
Methodological detailsmethodological study, bootstrapping (10 000 replications of each study), analysis of covariance adjusted for baseline scores
- Methodological study
- Bootstrapping (10 000 replications of each study)
- Analysis of covariance adjusted for baseline scores
Primary result
As reported in the abstract
Loss in power of SENS vs SHS
- Loss in power of SENS over SHS limited to at most 19% (BeSt year 5)
- Difference in power between SENS and SHS smaller at higher levels of power
Further findings
Criterion validity: Spearman correlation SENS vs SHS
- All correlations
- >0.9
- DRESS change score at 18 months
- 0.787
Original publication
Effect of using the Simple Erosion Narrowing Score or Sharp/van der Heijde score on the power of rheumatoid arthritis clinical trials to detect differences in radiographic progression. Rheumatology (Oxford). Published 12 June 2024. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →