EAT ‐Lancet Diet Modifies the Risk of Rheumatoid Arthritis Through Metabolomic Signature
Authors' conclusion
Greater adherence to the EAT-Lancet diet is linked to a reduced risk of RA, with significant mediation by the metabolomic signature
Study context
- Population
- UK Biobank participants free of rheumatoid arthritis (RA) at baseline1,897 RA cases
- Participants
- 205,439 participants
- Exposure
- EAT-Lancet diet index (per 10-point increment) and its metabolomic signature vs risk of incident RA
- Outcome
- Incident RA
- Follow-up
- Mean 13 years
Methodological detailsCox proportional hazards models, elastic net regression metabolomic signature, causal mediation analysis, genome-wide gene-environment interaction study
- Cox proportional hazards models
- Elastic net regression metabolomic signature
- Causal mediation analysis
- Genome-wide gene-environment interaction study
Main finding
As reported in the abstract
Hazard ratio (95% CI)
10-point increment of EAT-Lancet diet score
0.93(0.90–0.96)
10-point increment of corresponding metabolomic signature
0.80(0.70–0.93)
Observational data: associations, not effects.
Further findings
Mediation of diet–RA association by metabolomic signature
- Proportion mediated by metabolomic signature
- 34.07% (95% CI 21.44%-47.00%)
- Mainly via pathways related to inflammation, fatty acids and fluid balance; key mediators glycoprotein acetyls, docosahexaenoic acid, degree of unsaturation, omega-3 fatty acids, albumin
Gene-diet interaction
- Genes interacting with EAT-Lancet diet score: B2M, SLC30A4, SHF, SORD, CASC4, SPG11, CRIP2, BTBD6, TEX22
Original publication
EAT ‐Lancet Diet Modifies the Risk of Rheumatoid Arthritis Through Metabolomic Signature. Arthritis Rheumatol. Published 24 September 2025. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →