A prospective study of eating disorders and risk of rheumatoid arthritis
Main finding · Incident RAResult — go to the resultAdjusted hazard ratio 1.76 95 % CI 1.12–2.76Authors' conclusion
Our findings suggest that individuals with EDs may have a higher risk of developing RA, particularly in men.
Study context
- Population
- UK Biobank participants aged 40 to 69 free of RA at baseline (2006–2010)5,404 incident RA cases
- Participants
- 489,569 participants
- Exposure
- History of ED vs no ED
- Outcome
- Incident RA
Methodological detailsmultivariable-adjusted Cox proportional hazard models
- Multivariable-adjusted Cox proportional hazard models
Main finding
As reported in the abstract
median follow-up 12.5 years
Adjusted hazard ratio
1.76
95 % CI 1.12–2.76
EDvs No ED
aHR 1.76 (95 % CI 1.12–2.76)
Observational data: associations, not effects.
Further findings
| Outcome | aHR (95 % CI) | P value | |
|---|---|---|---|
| Incident RA by sex (men; women)EDvs No EDMen | 5.09 (2.13–12.1) | P for interaction = 0.033 | |
| Incident RA by sex (men; women)EDvs No EDWomen | 1.38 (0.82–2.34) | P for interaction = 0.033 | |
| 0.050.21520Adjusted hazard ratio (log scale) |
Original publication
A prospective study of eating disorders and risk of rheumatoid arthritis. Semin Arthritis Rheum. Published 24 October 2025. doi:10.
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