Early-life famine exposure and risk of osteoporosis and low bone mineral density: a systematic review and meta-analysis
Authors' conclusion
Early-life famine exposure is significantly associated with an increased risk of osteoporosis, fractures, and lower BMD in later life.
Study context
- Population
- Observational studies of early-life famine exposure and osteoporosis, bone mineral density (BMD) and fracture risk10 studies
- Comparison
- Early-life famine exposure vs no exposure
- Outcome
- Osteoporosis, BMD loss and fractures
Methodological detailsMantel-Haenszel method for OR, Hedges' g for SMD, meta-regression, Searches of MEDLINE/PubMed, Scopus, Web of Science, Embase and Google Scholar; 6147 initial studies
- Mantel-Haenszel method for OR
- Hedges' g for SMD
- Meta-regression
- Searches of MEDLINE/PubMed, Scopus, Web of Science, Embase and Google Scholar; 6147 initial studies
Pooled result
As reported in the abstract
Osteoporosis
Famine-exposed vs Non-exposedOdds ratio (95% CI)
I2 = 88%
2.12(1.35–3.34)
Fractures; I2 = 92%
1.58(1.07–2.33)
Further pooled results
Meta-regression and exposure stage
- Higher female prevalence strengthened the association with osteoporosis; higher ages strengthened the association with fractures
- Exposure during fetal and childhood stages particularly associated with increased risks of osteoporosis and fractures
Original publication
Early-life famine exposure and risk of osteoporosis and low bone mineral density: a systematic review and meta-analysis. Osteoporos Int. Published 13 September 2024. doi:10.
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