Assessing the causal relationship between plasma proteins and osteoporosis: novel insights into pathological mechanisms and therapeutic implications
Authors' conclusion
The study identified 8 potential drug targets for OP.
Study context
- Population
- Plasma protein pQTL data (Ferkingstad et al.) as exposure; Bone mineral density (BMD) summary statistics from the GWAS Catalog as outcomepQTL n = 35,559
- Outcome
- Potential therapeutic targets (plasma proteins) for osteoporosis (OP), with BMD as outcome
Methodological detailssummary data-based Mendelian randomization (SMR), colocalization analysis, enrichment analysis, protein-protein interaction (PPI) network analysis, drug prediction, molecular docking
- Summary data-based Mendelian randomization (SMR)
- Colocalization analysis
- Enrichment analysis
- PPI network analysis
- Drug prediction
- Molecular docking
Main finding
As reported in the abstract
Plasma proteins associated with OP (SMR and colocalization)
Proteins significant in SMR analysis
20
Potential drug targets supported by colocalization (PP.H4 > 0.8): GCKR, ERBB3, CFHR1, GPN1, SDF2, VTN, BET1L, SERPING1
8
Further findings
Biological significance and pharmacological value
- Proteins closely associated with immune function
- Molecular docking showed favorable binding of drugs to proteins, consistent with existing structural data
Original publication
Assessing the causal relationship between plasma proteins and osteoporosis: novel insights into pathological mechanisms and therapeutic implications. Osteoporos Int. Published 9 August 2024. doi:10.
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