The Healing and therapeutic effects of perioperative bisphosphonate use in patients with fragility fractures: meta-analysis of 19 clinical trials
Authors' conclusion
Treatment with BP during the perioperative period does not affect the healing process and has positive effects on therapy for patients with fragility fractures.
Study context
- Population
- Patients with fragility fractures; trials in PubMed, EMBASE, Web of Science and Cochrane Library published before February 2023
- Participants
- 2,543 patients19 clinical trials
- Comparison
- Perioperative bisphosphonate use vs non-perioperative use and vs no use
- Outcome
- Fracture healing rate, healing time, and new fractures
Methodological detailsrandom effects meta-analysis
- Random effects meta-analysis
Pooled result
As reported in the abstract
Fracture healing rate
Perioperative BPs vs Non-perioperative BPsRelative risk (95% CI)P value
vs non-perioperative use at 4-6 weeks post-surgically
1.06(0.81–1.38)
P = 0.69vs non-perioperative use at ≈10-12 weeks post-surgically
1.02(0.94–1.11)
P = 0.65Further pooled results
| Outcome | Mean difference (week) (95% CI) | P value | |
|---|---|---|---|
| Healing time (primary outcome) · ≈10-12 weeksPerioperative BPsvs Non-perioperative BPs | −0.19 (−1.03 to 0.64) | P = 0.65 | |
| −1.5−1−0.500.51Difference, week (linear scale) |
| Outcome | RR (95% CI) | P value | |
|---|---|---|---|
| New fractures (primary outcome)Perioperative BPsvs No BPsBP usevs without BPs use | 0.35 (0.17–0.73) | P = 0.005 | |
| 0.10.31310Relative risk (log scale) |
Safety
| Outcome | RR (95% CI) | P value | |
|---|---|---|---|
| Adverse experiences: fever, arthralgia, myalgiaPerioperative BPsvs No BPsFever | 23.78 (8.29–68.21) | P < 0.001 | |
| Adverse experiences: fever, arthralgia, myalgiaPerioperative BPsvs No BPsArthralgia | 10.20 (2.41–43.16) | P = 0.002 | |
| Adverse experiences: fever, arthralgia, myalgiaPerioperative BPsvs No BPsMyalgia | 9.42 (2.54–34.87) | P < 0.001 | |
| 0.050.21520Relative risk (log scale) |
Original publication
The Healing and therapeutic effects of perioperative bisphosphonate use in patients with fragility fractures: meta-analysis of 19 clinical trials. Osteoporos Int. Published 8 August 2024. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →