Lung-related risk factors associate with low bone mineral density in individuals with former tobacco exposure not meeting osteoporosis screening criteria
Authors' conclusion
Emphysema on chest CT scan independently associates with low BMD in tobacco-exposed individuals not meeting traditional osteoporosis screening criteria.
Study context
- Population
- Men and women ≥40 years with former tobacco exposure (≥10 pack years) not meeting study-defined (modified FRAX) osteoporosis screening criteria28% not meeting screening criteria
- Participants
- 472 men
- Exposure
- Lung-related risk factors and low bone mineral density (BMD)
- Outcome
- Prevalence of low BMD on DXA (total hip, femoral neck, lumbar spine) in individuals not meeting screening criteria
Methodological detailsadjusted for age, sex and diabetes
- Adjusted for age, sex and diabetes
Main finding
As reported in the abstract
Low BMD on DXA in participants not meeting screening criteria
Prevalence of low BMD
55%
CT-determined emphysema associated with low BMD
aOR 2.1 (95% CI [1.02, 4.42])
Observational data: associations, not effects.
Further findings
Other lung-related factors and low BMD
- Lung function, respiratory symptoms, pack years cigarette use and inhaled corticosteroid use not associated with low BMD
Original publication
Lung-related risk factors associate with low bone mineral density in individuals with former tobacco exposure not meeting osteoporosis screening criteria. Osteoporos Int. Published 19 August 2025. doi:10.
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