Spondyloarthritis & psoriatic arthritis
Dynamics of interleukin-23/interleukin-17 axis and type 1 regulatory T cells across disease stages in axial spondyloarthritis
Authors' conclusion
These findings indicate that IL-23-associated immune activity may be relatively more prominent in early axSpA and that differences in Tr1 cell-related regulation across disease stages could contribute to this pattern.
Study context
- Population
- Patients with nr-axSpA and r-axSpA; serum IL-17A and IL-23, peripheral CD4+IL-17A+ cells, monocytes, dendritic cells (DCs) and Tr1 cells
- Participants
- 20 vs 24
- Comparison
- nr-axSpA vs r-axSpA
- nr-axSpAn = 20
- r-axSpAn = 24reference
- Outcome
- Serum IL-23 and IL-17A levels, nr-axSpA vs r-axSpA
Methodological detailscross-sectional comparison, ELISA and flow cytometry, co-culture experiments
- Cross-sectional comparison
- ELISA and flow cytometry
- Co-culture experiments
Main finding
As reported in the abstract
- Higher serum IL-23 levels in nr-axSpA
- Serum IL-17A levels comparable between both groups
- nr-axSpA vs r-axSpA: P = 0.014
- nr-axSpA vs r-axSpA: P = 0.912
Original publication
Dynamics of interleukin-23/interleukin-17 axis and type 1 regulatory T cells across disease stages in axial spondyloarthritis. Clin Exp Rheumatol. Published 28 July 2025. doi:10.
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