Spondyloarthritis & psoriatic arthritis
Association of Contextual Factors With Sonographic Inflammatory and Structural Phenotypes in Patients With Psoriatic Arthritis: A Cross-Sectional Study
Authors' conclusion
Older age correlated with more severe inflammatory and structural lesions, reflecting either a more severe PsA phenotype or overlap with age-related changes. Higher synovitis and tenosynovitis scores in b/tsDMARD-exposed patients likely reflect disease severity rather than a direct effect of treatment.
Study context
- Population
- Patients with active psoriatic arthritis (PsA) undergoing ultrasound (US) evaluationmean age 47.2, 48% female
- Participants
- 115 patients
- Exposure
- Association of demographic and clinical factors with US lesion scores
- Outcome
- Total semiquantitative US scores (B-mode and Doppler; 64-joint, 16-enthesis, 34-tendon protocol) for synovitis, enthesitis, paratenonitis, tenosynovitis, joint bone erosion and new bone formation
Main finding
As reported in the abstract
Multivariable associations with US scores
- Age ≥ 60 years: inflammatory enthesitis score, adjusted β
- 6.37
- Age ≥ 60 years: structural enthesitis score, adjusted β
- 14.6
- Age ≥ 60 years: bone erosion score, β
- 2.53
- Age ≥ 60 years: New bone formation (NBF) score, β
- 13.7
- b/tsDMARD exposure: synovitis score, β
- 12.8
- b/tsDMARD exposure: tenosynovitis score, β
- 5.95
Observational data: associations, not effects.
Further findings
Baseline disease activity and US scores
- Mean Disease Activity Index for PsA (SD 12.9)
- 22.7
- Mean US synovitis score (SD 22.9)
- 35.6
- Mean US enthesitis score (SD 22.1)
- 30.1
Original publication
Association of Contextual Factors With Sonographic Inflammatory and Structural Phenotypes in Patients With Psoriatic Arthritis: A Cross-Sectional Study. J Rheumatol. Published 25 July 2025. doi:10.
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