Do the features of juvenile psoriatic arthritis change according to age? A comprehensive evaluation of the PeRA Research Group Registry
Authors' conclusion
Children with PsA seem to display two different phenotypes. Younger children have a female predominance, ANA positivity and uveitis, while older children have more axial involvement.
Study context
- Population
- Children with juvenile psoriatic arthritis (JPsA) followed for at least 6 months, 2010–2020, seven paediatric rheumatology centres in Turkey (PeRA Research Group Registry)46 male/41 female
- Participants
- 87 children
- Exposure
- Early-onset vs late-onset JPsA
- Early-onsetn = 12
- Outcome
- Clinical features of JPsA
- Follow-up
- At diagnosis
Methodological detailsmulticentre, registry-based, Evaluated retrospectively
- Multicentre
- Registry-based
- Evaluated retrospectively
Main finding
As reported in the abstract
- Mean age at diagnosis, years (SD 4.5)
- 11.9
- Psoriasis at diagnosis
- 57 (65.5%)
- Arthritis preceded psoriasis
- 10 (11.5%)
- Dactylitis
- 30 (34.5%)
- Nail pitting
- 28 (32.2%)
- Small joint involvement
- 36 (41.4%)
- Enthesitis
- 20 (23%)
- Sacroiliitis by MRI
- 11 (12.6%)
- ANA positive
- 35 (40.2%)
- Early-onset (<5 years)
- 12 (13.8%)
Observational data: associations, not effects.
Further findings
Early-onset vs late-onset features
- Uveitis and ANA positivity more common in the early-onset group
Active joint counts and activity scores · month 6 and last control
- Significant improvement vs baseline at month 6 and at the last control
Original publication
Do the features of juvenile psoriatic arthritis change according to age? A comprehensive evaluation of the PeRA Research Group Registry. Rheumatology (Oxford). Published 19 September 2023. doi:10.
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