Divergent gene signatures and neutrophil enrichment in lymph nodes of inflammatory arthritis patients
An erratum to this article was published (Arthritis Res Ther, 27 Oct 2026 ↗)
Authors' conclusion
This study provides novel insights into the immune landscape of lymph nodes in inflammatory arthritis, emphasizing an unexpected role for neutrophils in IA patients.
Study context
- Population
- ACPA-positive rheumatoid arthritis (RA) patients, ACPA-negative inflammatory arthritis patients (including psoriatic arthritis (PsA) and ACPA-negative RA) and healthy controls undergoing lymph node (LN) biopsy
- Participants
- 14 / 45 / 25
- Comparison
- ACPA-positive RA and ACPA-negative inflammatory arthritis (IA) vs healthy controls
- ACPA+ RAn = 14
- ACPA− IAn = 45
- Healthy controls (HCs)n = 25reference
- Outcome
- LN molecular and cellular alterations
Methodological detailsultrasound-guided LN biopsies, transcriptome analyses, quantitative PCR and immunohistochemistry
- Ultrasound-guided LN biopsies
- Transcriptome analyses, quantitative PCR and immunohistochemistry
Main finding
As reported in the abstract
- Distinct LN gene expression profiles in ACPA+ RA and ACPA− IA vs HCs
- ACPA+ RA: upregulation of genes associated with adaptive immunity
- ACPA− IA: higher expression of genes related to innate immune cell function
- qPCR: increased Cathepsin G mRNA expression in ACPA− IA
- Significantly elevated CD15+ neutrophil presence in LNs of IA patients vs HCs, irrespective of ACPA status and diagnosis (RA or PsA)
Original publication
Divergent gene signatures and neutrophil enrichment in lymph nodes of inflammatory arthritis patients. Arthritis Res Ther. Published 23 April 2025. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →