Autoinflammatory & rare systemic diseases
Distinct impact of malignancy and allergy on the clinical and immunological features of IgG4-related disease
Authors' conclusion
The clinical and immunological phenotypes of IgG4-RD differ among those with underlying diseases.
Study context
- Population
- Consecutive patients with IgG4-RD treated at Keio University Hospital, 2010–2021
- Participants
- 123 patients
- Exposure
- IgG4-RD with malignancy vs allergy alone vs neither
- Malignancyn = 18
- Allergyn = 57
- Idiopathicn = 48
- Outcome
- Clinical characteristics by group
Methodological detailssingle-centre, consecutive patients
- Single-centre
- Consecutive patients
Main finding
As reported in the abstract
- Age (years), malignancy vs allergy vs idiopathic: 70.1 vs. 54.4 vs. 64.9
- p<0.001
- Male (%), malignancy vs allergy vs idiopathic: 83.3 vs. 42.1 vs. 54.2
- p=0.008
- Smoking habits (%), malignancy vs allergy vs idiopathic: 77.8 vs. 42.1 vs. 43.8
- p=0.02
- Aorta/large vessel involvement (%), malignancy vs allergy vs idiopathic: 33.3 vs. 7.0 vs. 20.8
- p=0.02
- Overall survival significantly poorer in malignancy group
- p=0.02
Observational data: associations, not effects.
Further findings
Peripheral blood immunophenotyping (56 immune cell subsets)
- Increase in CXCR5+CD2-double negative T cells and decrease in naive CD8 T cells characteristic of malignancy group
Original publication
Distinct impact of malignancy and allergy on the clinical and immunological features of IgG4-related disease. Clin Exp Rheumatol. Published 14 October 2022. doi:10.
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