Disease Recapture Rates After Medication Discontinuation and Flare in Juvenile Idiopathic Arthritis: An Observational Study Within the Childhood Arthritis and Rheumatology Research Alliance Registry
Authors' conclusion
Approximately half of JIA flares post-discontinuation were recaptured within 6 months, but rates of recapture varied across JIA categories.
Study context
- Population
- Children with juvenile idiopathic arthritis (JIA) who discontinued csDMARDs or bDMARDs for well-controlled disease, then flared and restarted medication; Childhood Arthritis and Rheumatology Research Alliance (CARRA) registrycomplete data for inactive disease (ID) at 6 months
- Participants
- 333 children
- Outcome
- Inactive disease (PGA <1 and active joint count = 0) after flare
- Follow-up
- 6 months after flare
Methodological detailsregistry-based, multivariable model
- Registry-based
- Multivariable model
Main finding
As reported in the abstract
Recapture (inactive disease) rate
Recapture rate, whole cohort
55%
Range across JIA categories, from persistent oligoarthritis to systemic arthritis (P = 0.4)
47% to 69%
Observational data: associations, not effects.
Further findings
Inactive disease achieved · 12 months
- Approximately, children achieving ID
- 67%
Predictors of successful recapture (multivariable model)
- History of biologic drugs, OR
- 4.79 (95% CI 1.22-18.78)
- Reinitiation of biologic drugs, OR
- 2.74 (95% CI 1.62-4.63)
- Number of joints with limited range of motion, OR per 1 joint increase
- 0.83 (95% CI 0.72-0.95)
Original publication
Disease Recapture Rates After Medication Discontinuation and Flare in Juvenile Idiopathic Arthritis: An Observational Study Within the Childhood Arthritis and Rheumatology Research Alliance Registry. Arthritis Care Res (Hoboken). Published 21 December 2022. doi:10.
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