Disease activity in patients with rheumatoid arthritis increases serum levels of apolipoprotein C-III
Main finding · Serum ApoC3 levels by disease activity (adjusted for confounders)Result — go to the resultBeta coefficient 1.28 mg/dl 95% CI 0.16–2.39Authors' conclusion
The activity of the disease in patients with RA is independently associated with higher serum levels of ApoC3.
Study context
- Population
- Patients with rheumatoid arthritis (RA)
- Participants
- 430 patients
- Exposure
- Moderate or high disease activity vs remission
- Outcome
- Serum ApoC3 levels and their relationship with RA characteristics, especially inflammatory activity
Methodological detailsmultivariable regression analysis
- Multivariable regression analysis
Main finding
As reported in the abstract
Serum ApoC3 levels by disease activity (adjusted for confounders)
Beta coefficient
1.28 mg/dl
95% CI 0.16–2.39
P = 0.025
Observational data: associations, not effects.
Further findings
Classic cardiovascular (CV) risk factors and ApoC3
- Abdominal circumference, obesity, type 2 diabetes and circulating triglycerides significantly associated with higher ApoC3 serum levels
Treatments and ApoC3
- Use of prednisone, DMARDs and TNFi therapies associated with lower ApoC3 values
Original publication
Disease activity in patients with rheumatoid arthritis increases serum levels of apolipoprotein C-III. Clin Exp Rheumatol. Published 12 December 2021. doi:10.
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