Difficult-to-treat rheumatoid arthritis (D2T RA): clinical issues at early stages of disease
Authors' conclusion
In this cohort of patients newly diagnosed with RA, our results do not allow us to prove the influence of active disease according to DAS28. However, we did find that younger patients and those with elevated initial disability scores are more likely to develop D2T RA regardless of other factors.
Study context
- Population
- Patients with RA in the early stages of disease, multicentre, 2009 to 2018, followed up until January 2021
- Participants
- 631 patients
- Exposure
- Patients who developed D2T RA vs those who did not
- D2T RAn = 35
- Outcome
- Progression to D2T RA by disease activity (DAS28) in the early stages
Methodological detailsmulticentre, real-life conditions, multivariable logistic regression
- Multicentre
- Real-life conditions
- Multivariable logistic regression
Main finding
As reported in the abstract
Disease activity (DAS28) at early stages and progression to D2T RA
- Disease Activity Score (DAS28) not statistically significantly associated with D2T RA in final model
Observational data: associations, not effects.
Further findings
- Incidence of D2T RA
- 5.87% · 35
Disability and D2T RA
- Disability independently associated with D2T RA (OR)
- 1.89
- P
- P = 0.01
Characteristics at diagnosis
- D2T RA group younger, with higher disability, DAS28, tender joint count and pain scores
Therapy
- No differences between groups for therapy
Original publication
Difficult-to-treat rheumatoid arthritis (D2T RA): clinical issues at early stages of disease. RMD Open. Published 8 March 2023. doi:10.
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