Lupus & antiphospholipid syndrome
Differential expression of interferon (IFN)-α, IL-12 and BAFF on renal immune cells and its relevance to disease activity and treatment responsiveness in patients with proliferative lupus nephritis
Authors' conclusion
The immunohistochemistry (IHC) of IFN-α, IL-12 and BAFF for proliferative LN enabled grouping. Especially, the IFN-α and IL-12 groups showed different clinicopathological features and renal prognoses.
Study context
- Population
- Patients with proliferative lupus nephritis (LN) (class III n=18, class IV n=32); renal tissue immunohistochemistry (IHC)
- Participants
- 50 proliferative LN cases
- Exposure
- Proliferative LN subgroups by dominant renal expression of IFN-α, IL-12/p40 or BAFF
- IFN-αn = 17
- IL-12n = 16
- BAFFn = 17
- Outcome
- Clinicopathological features by dominant cytokine subgroup
Methodological detailsimmunohistochemical analysis of renal biopsy tissue, comparison with controls
- Immunohistochemical analysis of renal biopsy tissue
- Comparison with controls
Main finding
As reported in the abstract
- Hypocomplementaemia and glomerular endocapillary hypercellularity significantly increased in the IFN-α group
- p<0.05
- Chronic lesions significantly higher in the IL-12 group
- p<0.05
Observational data: associations, not effects.
Further findings
Renal prognosis in treatment response · 52 weeks
- IFN-α group had a poorer renal prognosis
Original publication
Differential expression of IFN-α, IL-12 and BAFF on renal immune cells and its relevance to disease activity and treatment responsiveness in patients with proliferative lupus nephritis. Lupus Sci Med. Published 17 July 2023. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →