Different phenotypic manifestations between Brazilian and Japanese anti-MDA5 antibody-positive dermatomyositis: an international tricentric longitudinal study
Authors' conclusion
Brazilian patients with anti-MDA5(+) DM/ADM had a higher prevalence of skin and muscle involvement, whereas the prevalence of ILD and RP-ILD was significantly lower than in Japanese patients.
Study context
- Population
- Patients diagnosed with anti-MDA5(+) dermatomyositis (DM) or amyopathic DM at one Brazilian and two Japanese tertiary centres
- Participants
- 34 vs 65
- Exposure
- Brazilian vs Japanese patients with anti-MDA5 DM/amyopathic DM (ADM)
- Braziliann = 34
- Japanesen = 65reference
- Outcome
- Phenotypic differences, with particular focus on interstitial lung disease (ILD)
Methodological detailsinternational, tricentric, longitudinal, one Brazilian and two Japanese tertiary centres, pre-standardised protocol
- International
- Tricentric
- Longitudinal
- One Brazilian and two Japanese tertiary centres
- Pre-standardised protocol
Main finding
As reported in the abstract
Prevalence of ILD
P < 0.001
Observational data: associations, not effects.
Further findings
RP-ILD
P < 0.001
Age at diagnosis
- Brazilian patients younger at diagnosis than Japanese
Clinical manifestations
- Muscle weakness, myalgia, dysphagia, heliotrope rash, V-sign, calcinosis, RP and digital ulcers more prevalent in Brazilian patients
- Mechanic's hands more prevalent in Japanese patients
Overall survival, relapses and complications (severe infection, malignancy)
- Comparable between the two populations
Original publication
Different phenotypic manifestations between Brazilian and Japanese anti-MDA5 antibody-positive dermatomyositis: an international tricentric longitudinal study. Clin Exp Rheumatol. Published 13 August 2024. doi:10.
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