Spondyloarthritis & psoriatic arthritis
Differences in the response to TNF inhibitors at distinct joint locations in patients with psoriatic arthritis: results from nine European registries
Authors' conclusion
The time to resolution of joint swelling upon treatment with TNFi in patients with PsA seems to depend on the localisation of the affected joints.
Study context
- Population
- Bionaive PsA patients from nine European countries with ≥ 1 swollen joint at initiation of a first TNFi as monotherapy or added to MTX8,397 swollen joints
- Participants
- 1,729 patients
- Exposure
- Joint locations compared with the joints of digit 3
- Outcome
- Time to first resolution of joint swelling at each joint level
Methodological detailsmultinational (nine European registries), interval-censored mixed-effects Cox proportional hazards models, adjusted for age and sex, Only the 28-joint count was available without imaging data confirming the presence of synovitis
- Multinational (nine European registries)
- Interval-censored mixed-effects Cox proportional hazards models
- Adjusted for age and sex
- Only the 28-joint count was available without imaging data confirming the presence of synovitis
Main finding
As reported in the abstract
Time to first resolution of joint swelling, by joint location (HR >1 = higher rate of resolution)
HR for resolution of joint swelling (95% CI)
Shouldervs Digit 3higher rate of resolution
1.65(1.16–2.35)
Elbowvs Digit 3higher rate of resolution
1.90(1.38–2.61)
Wristvs Digit 3lower rate of resolution
0.72(0.62–0.83)
Digit 4vs Digit 3resolved fastest within fingers
1.77(1.49–2.11)
Digit 5vs Digit 3resolved fastest within fingers
1.88(1.53–2.31)
Kneevs Elbowlower rate of resolution
0.56(0.40–0.78)
Observational data: associations, not effects.
Original publication
Differences in the response to TNF inhibitors at distinct joint locations in patients with psoriatic arthritis: results from nine European registries. Arthritis Res Ther. Published 31 January 2025. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →