Lupus & antiphospholipid syndrome
Differences in IgG Sialylation Distinguish Asymptomatic From Symptomatic Antinuclear Antibody–Positive Individuals
Authors' conclusion
The absence of proinflammatory factors in ANA+NS does not result from a lack of circulating ICs but instead may reflect differences in the extent of IgG sialylation in the ICs from ANA+NS as compared to those with SARD.
Study context
- Population
- Healthy controls, asymptomatic antinuclear antibody (ANA)+ individuals and symptomatic ANA+ patients
- Participants
- 18 / 31 / 51
- Comparison
- ANA-HC vs ANA+NS vs symptomatic ANA+ patients
- ANA-HCn = 18reference
- ANA+NSn = 31
- Symptomatic ANA+n = 51
Methodological detailsflow cytometry, coculture with monocytes or moDCs, ELISA or lectin blotting for IgG sialylation
- Flow cytometry
- Coculture with monocytes or moDCs
- ELISA or lectin blotting for IgG sialylation
Main finding
As reported in the abstract
- All ANA+ individuals had higher numbers of total and IgG-coated microparticles (MPs) than ANA-HC
- IgG sialylation significantly reduced in systemic autoimmune rheumatic disease (SARD) vs ANA+NS and ANA-HC, and in ANA+NS who clinically progressed in the next two years vs those who did not
- moDCs stimulated with IgG-coated MPs or aggregated IgG from SLE patients produced significantly more TNFα than those from ANA+NS
- TNFα levels in culture supernatants and serum negatively correlated with IgG sialylation
Original publication
Differences in IgG Sialylation Distinguish Asymptomatic From Symptomatic Antinuclear Antibody–Positive Individuals. Arthritis Rheumatol. Published 11 November 2025. doi:10.
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