Lupus & antiphospholipid syndrome
Distinct changes in nailfold capillaries are associated with the clinical and serological features of patients with systemic lupus erythematosus
Authors' conclusion
Capillaroscopic alterations are common in patients with SLE, and capillary ramifications and dilations are linked to distinct SLE phenotypes.
Study context
- Population
- Patients with systemic lupus erythematosus (SLE) (median SLEDAI 6, IQR 3–10)
- Participants
- 56 patients
- Exposure
- Nailfold videocapillaroscopy (NVC) clusters: ramification-dominated vs dilatation-dominated vs unspecific reference cluster
- Ramificationsn = 16
- Dilationsn = 10
- Outcome
- Association of distinct NVC patterns with distinct SLE phenotypes
Methodological detailshierarchical cluster analysis of principal components, multinomial logistic regression
- Hierarchical cluster analysis of principal components
- Multinomial logistic regression
Main finding
As reported in the abstract
- Ramifications
- 66%
- Disorganisation
- 89%
- Tortuous appearance
- 75%
- Low density
- 86%
- Meandering appearance
- 52%
- Dilatations
- 23%
- Microhaemorrhages
- 29%
Observational data: associations, not effects.
Original publication
Distinct changes in nailfold capillaries are associated with the clinical and serological features of patients with systemic lupus erythematosus. Semin Arthritis Rheum. Published 10 November 2025. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →