Spondyloarthritis & psoriatic arthritis
Differences between early vs. late-onset of psoriatic arthritis: Data from the RESPONDIA and REGISPONSER registries
Authors' conclusion
Patients with late-onset PsA showed different clinical characteristics and greater disease severity than those with early-onset PsA.
Study context
- Population
- Patients with psoriatic arthritis (PsA) with < 10 years of disease duration from the REGISPONSER and RESPONDIA registries
- Participants
- 231 patients
- Exposure
- Late-onset vs early-onset PsA
- Outcome
- Characteristics and burden of the disease by age at PsA symptom onset; factors independently associated with late-onset PsA
Methodological detailsobservational, registry-based (REGISPONSER and RESPONDIA), multivariate logistic regression
- Observational
- Registry-based (REGISPONSER and RESPONDIA)
- Multivariate logistic regression
Main finding
As reported in the abstract
Factors independently associated with late-onset PsA (logistic regression)
Each group vs early onsetEstimate (95% CI)
Late onset
OR (male sex) 4.4(1.3–16.3)
Late onset
OR (greater structural damage, total BASRI) 3.3(1.3–8.1)
Late onset
OR (higher frequency of upper-limb arthritis) 2.8(1–7.7)
Late onset
OR (greater loss of function, BASFI) 1.3(1–1.6)
Observational data: associations, not effects.
Further findings
Male sex
Enthesitis
Sacroiliitis
| Outcome | Early onset | Late onset |
|---|---|---|
| BASFISpread printed in parentheses without its kind named | 2.2 (SD 2.2) | 3.3 (SD 2.5) |
| Spine structural damage (BASRI)Spread printed in parentheses without its kind named | 1.6 (SD 2) | 2.9 (SD 3) |
| Whole axial skeleton structural damage (total BASRI)Spread printed in parentheses without its kind named | 1.9 (SD 2.4) | 3.4 (SD 3.4) |
Male sex
- Significantly lower prevalence of males in early onset
Disease activity (BASDAI and ASDAS)
- No statistically significant differences between the groups
Original publication
Differences between early vs. late-onset of psoriatic arthritis: Data from the RESPONDIA and REGISPONSER registries. Joint Bone Spine. Published 17 March 2023. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →