Diagnosis of calcium pyrophosphate crystal deposition disease by ultrasonography: how many and which sites should be scanned?
Authors' conclusion
Bilateral US assessment of knees, wrists and hips had excellent accuracy and good feasibility for the diagnosis of CPPD disease.
Study context
- Population
- Consecutive patients with crystal-proven CPPD disease and age-, sex-matched disease controls, two Italian institutions
- Participants
- 204 patients
- Comparison
- Reduced US protocol (bilateral knees, wrists and hips) vs 20-joint standardized US protocol for diagnosis of CPPD disease
- CPPD diseasen = 102
- Disease controlsn = 102reference
- Outcome
- Diagnostic accuracy (AUC) of reduced US scanning protocols for CPPD disease
Methodological detailscross-sectional, prospective, consecutive patients, age-, sex-matched disease controls, two Italian institutions, sonographers blinded to clinical details, LASSO joint selection, training and validation sets
- Cross-sectional
- Prospective
- Consecutive patients
- Age-, sex-matched disease controls
- Two Italian institutions
- Sonographers blinded to clinical details
- LASSO joint selection
- Training and validation sets
Performance
As reported in the abstract
Reduced US protocol (bilateral knees, wrists, hips), CPPD in ≥2 joints
Sensitivity, 95% CI 82.8, 99.9
96.7%
Specificity, 95% CI 88.8, 100.0
100
Feasibility, scan time, mean (SD 5.3) min
12.5
Further findings
Median
| Outcome | CPPD disease | Disease controls | P value |
|---|---|---|---|
| Number of joints with US evidence of CPPD | 5 (IQR 4–7) | 0 (IQR 0–1) | P < 0.01 |
Original publication
Diagnosis of calcium pyrophosphate crystal deposition disease by ultrasonography: how many and which sites should be scanned? Rheumatology (Oxford). Published 26 October 2023. doi:10.
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