Development and external validation of prediction models for major osteoporotic fracture and hip fracture in people with intellectual disability
Authors' conclusion
IDFracture has potential as a screening tool in clinical practice to identify people with ID who are at increased risk of MOF and HF.
Study context
- Population
- People with ID aged 30–79 years
- Outcome
- 10-year risk of HF and MOF
- Follow-up
- 10 years
Methodological detailsCox regression, bootstrapping to adjust for overfitting, temporal validation
- Cox regression
- Bootstrapping to adjust for overfitting
- Temporal validation
Performance
As reported in the abstract
Discrimination (C statistic), external validation
C statistic, major osteoporotic fracture (MOF)
0.775
C statistic, hip fracture (HF)
0.839
Further findings
| Outcome | Development | External validation |
|---|---|---|
| Fracture events within 10 years | ||
| MOFs | 1045 | 2420 |
| HFs | 360 | 1001 |
Parts of this Brief are withheld: the automatic checks could not confirm them against the abstract.
Original publication
Development and external validation of prediction models for major osteoporotic fracture and hip fracture in people with intellectual disability. Osteoporos Int. Published 20 April 2026. doi:10.
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