The systemic inflammation response index is independently associated with incident fracture risk in older women
Authors' conclusion
SIRI was positively and independently associated with incident fracture risk.
Study context
- Population
- Swedish women aged 75–80 yearsmedian follow-up 8 years
- Participants
- 2,965 women
- Exposure
- Higher vs lower systemic inflammation response index
- Outcome
- Incident fracture (hip fracture, MOF, any fracture)
Methodological detailsCox proportional hazards regression
- Cox proportional hazards regression
Main finding
As reported in the abstract
Incident fracture, HR per 1 SD increase in SIRI, adjusted for age, BMI, CRFs and FN BMD
- Hip fracture (230 events): HR per 1 SD increase 1.18, 95% CI 1.07-1.32, p < 0.01
- Major osteoporotic fractures (MOF) (790 events): HR per 1 SD increase 1.10, 95% CI 1.03-1.18, p < 0.01
- Any fracture (1059 events): HR per 1 SD increase 1.11, 95% CI 1.05-1.17, p < 0.001
- Independent of age, BMI, clinical risk factors (CRFs) and FN BMD
Observational data: associations, not effects.
Further findings
Physical function and activity, systemic inflammation response index (SIRI) Q5 vs Q1
- TUG (poorer physical function), Q5 vs Q1, p < 0.05
- 11.8%
- PASE (lower activity), Q5 vs Q1, p < 0.05
- −28.8%
Bone microstructure and BMD
- SIRI positively associated with cortical porosity and trabecular number, but not with BMD by DXA
Original publication
The systemic inflammation response index is independently associated with incident fracture risk in older women. Osteoporos Int. Published 20 April 2026. doi:10.
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