Lupus & antiphospholipid syndrome
Development and external validation of a prediction model for interstitial lung disease in systemic lupus erythematosus patients: A cross-sectional study
Authors' conclusion
We established a nomogram model using easily accessible clinical and laboratory data to predict the probability of female SLE patients of reproductive age developing ILD.
Study context
- Population
- Female systemic lupus erythematosus (SLE) patients of reproductive age; Interstitial lung disease (ILD) prediction2,488 development, 2310 external validation
- Participants
- 4,798 patients
- Exposure
- Training vs Internal testing vs External validation
- Trainingn = 1,742
- Internal testingn = 746
- External validationn = 2,310
- Outcome
- Nomogram identifying ILD in female SLE patients of reproductive age
Methodological detailsprediction model development, internal and external validation, nomogram
- Prediction model development
- Internal and external validation
- Nomogram
Main finding
As reported in the abstract
Nomogram discrimination for ILD (AUC)
- Independent risk factors for ILD: APOB, APOA1, ALP, PLT, HCT, EOS-R, LYM-R and age
- 8
Observational data: associations, not effects.
Parts of this Brief are withheld: the automatic checks could not confirm them against the abstract.
Original publication
Development and external validation of a prediction model for interstitial lung disease in systemic lupus erythematosus patients: A cross-sectional study. Semin Arthritis Rheum. Published 11 October 2024. doi:10.
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