Autoinflammatory & rare systemic diseases
Detection of hypophosphatasia in hospitalised adults in rheumatology and internal medicine departments: a multicentre study over 10 years
Authors' conclusion
In this 10-year retrospective study, 0.32% of adult patients hospitalised in the rheumatology and internal medicine departments had persistently low serum ALP, and among them, 6% had genetically proven HPP.
Study context
- Population
- Adults hospitalised in rheumatology and internal medicine departments of six University Hospitals in France, 2007–2017, with at least 2 serum alkaline phosphatase (ALP) dosages664 with ≥2 low serum ALP
- Participants
- 56,321 adults
- Exposure
- Fluctuating low values vs Persistent low values
- Fluctuating low valuesn = 482
- Persistent low valuesn = 182
- Outcome
- Low serum ALP (≤35 UI/L) and genetically proven HPP
Methodological detailssix University Hospitals in France, 10 years
- Six University Hospitals in France
- 10 years
Main finding
As reported in the abstract
Values
Mean age (years) Fluctuating low values 62.9 · Persistent low values 53.4
Women
- Adult hospitalised patients with persistently low serum ALP
- 0.32%
- Genetic diagnosis of hypophosphatasia (HPP) in persistent hypophosphatasaemia
- at least 6.0%
- Genetic diagnosis of HPP in patients with at least three symptoms suggestive of HPP
- at least 15.9%
- Genetic testing performed / positive
- 18 / 11
Observational data: associations, not effects.
Further findings
Bisphosphonate-treated patients with persistent hypophosphatasaemia
- Never had ALP measurement before treatment
- 70.8%
- Treated despite an abnormal decrease of ALP
- 20.8%
Reported hypophosphatasaemia
- Proportion of hospitalised patients
- 3.6%
Original publication
Detection of hypophosphatasia in hospitalised adults in rheumatology and internal medicine departments: a multicentre study over 10 years. RMD Open. Published 4 April 2024. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →