Autoinflammatory & rare systemic diseases
Joint involvement in VEXAS and non-VEXAS clonal haematopoiesis: two clusters from a multicentre regional cohort
Authors' conclusion
Joint involvement was more frequent in patients with clonal haematopoiesis and dysimmune manifestations unrelated to VEXAS syndrome.
Study context
- Population
- Patients with a haematological disorder associated with dysimmune manifestations screened for UBA1 mutations, December 2019–January 2023, 7 Normandie (France) hospitals
- Participants
- 30 patients
- Exposure
- Clonal haematopoiesis with UBA1 mutations vs without UBA1 mutations
- Non-VEXASn = 17
- VEXASn = 13reference
- Cluster 1n = 14
- Cluster 2n = 16reference
- Outcome
- Joint involvement (arthralgia/arthritis)
Methodological detailsmulticentre, unsupervised hierarchical clustering
- Multicentre
- Unsupervised hierarchical clustering
Main finding
As reported in the abstract
p value: 0.016
Observational data: associations, not effects.
Further findings
| Outcome | Cluster 1 | Cluster 2 | P value |
|---|---|---|---|
| Clusters: joint involvementCluster 1 vs Cluster 2 | 93% | 25% | p value: 0.001 |
| Clusters: UBA1 mutationCluster 1 vs Cluster 2 | 14% | 69% | p value: 0.008 |
| Clusters: pulmonary involvementCluster 1 vs Cluster 2 | 7% | 50% | p value: 0.017 |
| Clusters: chondritisCluster 1 vs Cluster 2 | 0% | 50% | p value: 0.003 |
| Clusters: unprovoked venous thrombosisCluster 1 vs Cluster 2 | 7% | 43% | p value: 0.039 |
| Clusters: ASXL1 mutations | 21% | 0% |
Original publication
Joint involvement in VEXAS and non-VEXAS clonal haematopoiesis: two clusters from a multicentre regional cohort. RMD Open. Published 29 October 2025. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →