Depression and anxiety in childhood-onset systemic lupus erythematosus: prevalence, associated factors, and impact on quality of life and family
Authors' conclusion
These results suggest that depression and anxiety are prevalent in cSLE and have negative impacts on HRQOL and family.
Study context
- Population
- cSLE patients aged 8–18 years
- Participants
- 91 patients
- Outcome
- Prevalence of clinically significant depression (CDI > 15) and anxiety (SCARED ≥ 25)
Main finding
As reported in the abstract
Clinically significant depression (Children's Depression Inventory (CDI) > 15)
31.9%
Clinically significant anxiety (Screening for Child Anxiety Related Disorders (SCARED) ≥ 25)
49.5%
Coexisting clinically significant depression and anxiety
26 patients
28.6%
Observational data: associations, not effects.
Further findings
Factors associated with clinically significant depression (multivariable)
| OR (95% CI) | P value | ||
|---|---|---|---|
| Older age at diagnosis | 1.56 (1.12–2.16) | P = 0.008 | |
| 0.512Odds ratio (log scale) |
Factors associated with clinically significant anxiety (multivariable)
| OR (95% CI) | P value | ||
|---|---|---|---|
| Organ damage | 4.27 (1.19–15.31) | P = 0.026 | |
| Pain score | 1.61 (1.11–2.32) | P = 0.012 | |
| 0.050.21520Odds ratio (log scale) |
Health-related quality of life (HRQOL) (PedsQL-GC) and family impact (PedsQL family impact)
- Patients with clinically significant depression or anxiety had significantly lower PedsQL-GC and PedsQL family impact scores than those without
Original publication
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