Degenerative scoliosis may trigger higher incidence of adjacent vertebral fractures following percutaneous vertebroplasty: a clinical evidence-based biomechanical research
Authors' conclusion
Supported by consistent clinical and biomechanical evidence, DS is associated with a higher incidence of AVF, likely due to biomechanical factors, and patients with DS should be considered high-risk after PVP.
Study context
- Population
- Patients with osteoporotic vertebral compression fractures treated with percutaneous vertebroplasty (PVP)
- Exposure
- Patients with vs without adjacent vertebral fracture (AVF) after PVP; biomechanical models with pronounced vs no or mild scoliosis
- Outcome
- Scoliosis angle between adjacent cranial and caudal vertebrae and DS incidence (DS = scoliosis angle > 10°) in patients with vs without AVF
Methodological detailsregression analyses, biomechanical models with varying scoliosis angles
- Regression analyses
- Biomechanical models with varying scoliosis angles
Main finding
As reported in the abstract
Scoliosis angle and DS incidence
- Patients with AVF had significantly larger scoliosis angles and higher degenerative scoliosis (DS) incidence than those without AVF
- Both parameters were independent risk factors for AVF
Observational data: associations, not effects.
Further findings
Stress in vertebrae adjacent to PVP-treated levels (biomechanical models)
- Models with pronounced scoliosis showed markedly higher stress in adjacent vertebrae under most loading conditions vs non-scoliotic or mildly scoliotic models
Original publication
Degenerative scoliosis may trigger higher incidence of adjacent vertebral fractures following percutaneous vertebroplasty: a clinical evidence-based biomechanical research. Osteoporos Int. Published 12 November 2025. doi:10.
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