Vasculitis & polymyalgia rheumatica
Deficiency of peripheral cutaneous lymphocyte antigen (CLA)+ Tregs and clinical relevance in Behcet’s syndrome
Authors' conclusion
CLA+ Tregs decrease in association with arterial aneurysm in patients with BS.
Study context
- Population
- Patients with Behcet's syndrome and healthy controls; peripheral blood
- Participants
- 107 vs 114
- Comparison
- BD vs healthy controls
- Behcet's syndrome (BS)n = 107
- Healthy controls (HCs)n = 114reference
- Outcome
- Number and proportion of peripheral CLA+ Tregs
Methodological detailsflow cytometry
- Flow cytometry
Main finding
As reported in the abstract
Absolute number and proportion of CLA+ Tregs among CD4+ T lymphocytes and CD4+ Tregs
- Lower in patients with BS than in HCs
Observational data: associations, not effects.
Further findings
Correlations of CLA+ Tregs with other cells in BS
- Natural killer (NK) cells, r
- 0.500, P < 0.001
- B cells, r
- 0.470, P < 0.001
- Effector T cells, r
- −0.402, P < 0.001
Arterial aneurysms in BS
- CLA+ Treg deficiency in BS with arterial aneurysms; decreased proportion associated with arterial aneurysms
Treatment
- Proportion of CLA+ Tregs in BS increased with corticosteroids and immunosuppressants
Original publication
Deficiency of peripheral CLA+ Tregs and clinical relevance in Behcet’s syndrome. Arthritis Res Ther. Published 21 March 2024. doi:10.
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