Cytokine/chemokine profiles in rheumatoid arthritis patients who failed Boolean remission solely due to elevated patient global assessment
Authors' conclusion
RA patients with near-remission exhibited a distinct inflammatory phenotype characterized by persistent IL-1β elevation and maintained cytokine network density.
Study context
- Population
- Rheumatoid arthritis (RA) patients receiving b/tsDMARDs
- Participants
- 200 patients
- Exposure
- Near-remission vs complete remission vs non-remission
- Group 0n = 68reference
- Group 1n = 50
- Group 2n = 82
- Outcome
- Cytokine/chemokine profiles (41 cytokines/chemokines and auto-antibodies)
Methodological detailsstratified by 12-month Boolean remission status, network analysis
- Stratified by 12-month Boolean remission status
- Network analysis
Main finding
As reported in the abstract
- 12 months: Group 1 persistent IL-1β elevation; Groups 0 and 2 undetectable
- P = 0.007
Observational data: associations, not effects.
Original publication
Cytokine/chemokine profiles in rheumatoid arthritis patients who failed Boolean remission solely due to elevated patient global assessment. Rheumatology (Oxford). Published 18 January 2026. doi:10.
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