Distinct clinical outcomes based on multiple serum cytokine and chemokine profiles rather than autoantibody profiles and ultrasound findings in rheumatoid arthritis: a prospective ultrasound cohort study
Authors' conclusion
Specific patterns of cytokines and chemokines-no other clinical factors and autoantibody profiles-were important to distinguish patients with RA achieving remission at 12 months.
Study context
- Population
- Patients with rheumatoid arthritis (RA) treated with b/tsDMARDs
- Participants
- 200 patients
- Outcome
- CDAI remission
- Follow-up
- 12 months
Methodological detailsmulticentre, ultrasound cohort, Serum cytokines, chemokines, RF, anti-CCP2 and anti-carbamylated protein antibodies measured at baseline, 3 months and 12 months
- Multicentre
- Ultrasound cohort
- Serum cytokines, chemokines, RF, anti-CCP2 and anti-carbamylated protein antibodies measured at baseline, 3 months and 12 months
Main finding
As reported in the abstract
Predictors of CDAI remission
- Dimensionality reduction using 38 cytokines and chemokines showed four distinct clusters differing significantly in frequencies of remission (clinical composite measures and US evaluations)
- Between-cluster differences characterised by IL-1β, IL-5, IL-7, IL-10, IFNγ, GRO, IP-10, MCP-1 and MIP-1β
- Two groups made of the four clusters differed significantly in IgM-anti-CCP2 positivity
- LASSO regression of 38 cytokines and chemokines for Clinical Disease Activity Index (CDAI) remission at 12 months selected MIP-1β
- In logistic regression (baseline ACPA, IgM-anti-CCP2 positivity, CDAI, total power Doppler score, cytokine/chemokine cluster, MIP-1β, MTX dose, mechanisms of action), cytokine/chemokine cluster was the sole significant factor for CDAI remission at 12 months
Observational data: associations, not effects.
Original publication
Distinct clinical outcomes based on multiple serum cytokine and chemokine profiles rather than autoantibody profiles and ultrasound findings in rheumatoid arthritis: a prospective ultrasound cohort study. RMD Open. Published 25 January 2025. doi:10.
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